Environment: Xenapp 6.5 HRP05 published desktops – supporting 20000 users across 2 data centres.
Issue: Lync screen sharing failing between published desktop sessions between the 2 data centres – all ok within sessions that are occurring in the same data centre.
Come across this posting http://www.vikenes.no/2012/06/lync-sharing-ends-due-to-network-issue
And it pointed to a similar issue, spoke about endpoint agent and a different version of lync but I did update the image I was working on and removed the agent. So far it has been rock solid, tried now 10 different users in the EDC with both iFlex and QIC systems and 7/8 in the ADC with a mix of both and have been able to screenshare on every occasion.
So fix as per above URL
Add the lync.exe exclusion added to edgesight agent exclusion list