Can be a bit of challenge for app-v newbies when troubleshooting issues relating to app-v particularly if using them in a SCCM/App-V setup in a citrix environment as there is a number of moving parts at play.
One simple tip to help you encountering issues relating to app-v launches is to open up the level of event logging on the citrix server relating to app-v events as generally the defaults are never enough to give an adequate picture of what is going on.
i) Logon to the citrix server encountering the issue (preferably admin level access)
ii) go into the event viewer (eventvwr.exe)
iii) Click on View | Show Analytic and Debug Logs
iv) Click on Applications and Services Logs then on left-hand pane and Microsoft | AppV
v) Under there generally i pick logs under Client and Streaming VFS – if you click into the folders and right-click the appropriate log and choose Enable log you should start getting more information back regards the cause of the errors