Further to an earlier post i did relating to a similar error message I did come across this issue again in 2 separate environments. Oddly v.uneven in how often it would happen but it would only occur with the app-v published applications we had.
Summary of environments
Both Xenapp 7.13
VDA’s running 7.15
Published to VDA’s running MCS and PVS images respectively.
Band-aid fix was to reset the profile in Director. Did see instances of “bad” profiles having files in their AppData\local\Microsoft\Credentials folder but a removal didn’t do anything.
Ultimately came down to controller version. Upgrading environments to the 7.15 LTSR resolved the issue. If you review the readme for 7.15 it details the fix specifically:
When launching an App-v package using the Microsoft App-V 5.0 infrastructure integrated with XenDesktop, the App-V package might fail to synchronize and the following exception occurs:
“Cannot start <applicationname>” [#LC5483]